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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract: Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcriptionThis review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 3-22 doi: 10.1007/s11684-017-0605-9

Abstract:

For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing. Nevertheless, frequent infectious disease outbreaks/events have been reported almost every year, and imported infectious diseases have increased since 2015. New pathogens and over 100 new genotypes or serotypes of known pathogens have been identified. Some infectious diseases seem to be exacerbated by various factors, including rapid urbanization, large numbers of migrant workers, changes in climate, ecology, and policies, such as returning farmland to forests. This review summarizes the current experiences and lessons from China in managing emerging and re-emerging infectious diseases, especially the effects of ecology, climate, and behavior, which should have merits in helping other countries to control and prevent infectious diseases.

Keywords： infectious disease profile     emerging infectious diseases     influence factor    

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Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey of the English literature

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 94-99 doi: 10.1007/s11684-012-0181-y

Abstract: The total number of articles, impact factors (IF), and articles published in high-impact journals wereResearchers from HK published a larger proportion of papers in high-impact journals than those from ML

Keywords： systematic review     meta-analysis     China     Chinese     impact factor    

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Game theoretic analysis of environmental impact assessment system in China

CHENG Hongguang, PU Xiao, GONG Li, QI Ye

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 4,   Pages 448-453 doi: 10.1007/s11783-007-0071-8

Abstract: Environmental impact assessment (EIA) system has been established in China since 1973.

Keywords： public     impact assessment     Environmental impact     general    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Dynamical analysis of droplet impact spreading on solid substrate

Zhaomiao LIU, Huamin LIU, Xin LIU,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 308-315 doi: 10.1007/s11465-010-0020-2

Abstract: This paper investigates the impact spreading of a droplet on a solid substrate using numerical simulationThe pressure, velocity, and spreading factor during the droplet spreading are reported.According to the spreading factor’s evolvement, the process of droplet spreading can be classifiedThe impact speed impacts on the spreading factors in high speed droplet spreading.The spreading factor obviously increases with increasing impact speed; however, splashing will appear

Keywords： droplet     impact spreading     numerical simulation    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional targetAn understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 871-881 doi: 10.1007/s11709-022-0863-8

Abstract: failure criteria of practical soil mass are very complex, and have significant influence on the safety factorto determine the failure criterion, the limit equilibrium method can be used to calculate the safety factorAnalysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum

Keywords： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1015-1024 doi: 10.1007/s11783-014-0670-0

Abstract: land area types with different levels of productivity, they introduced the concept of an equivalence factorSecondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land andbuilt-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41,pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land areaThe NPP of each ecosystem type varies along with the equivalence factor in different provinces.

Keywords： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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Comparison of droplet distributions from fluidic and impact sprinklers

Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 53-59 doi: 10.15302/J-FASE-2015049

Abstract: prototype sprinklers, outside signal sprinkler (OS) and fluidic sprinkler (FS), were compared with impact

Keywords： outside signal sprinkler     fluidic sprinkler     impact sprinkler     sprinkler irrigation     droplet size     droplet    

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Mechanical properties and impact resistance of concrete composites with hybrid steel fibers

Fatih ÖZALP; Halit Dilşad YILMAZ; Burcu AKCAY

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 5,   Pages 615-623 doi: 10.1007/s11709-022-0828-y

Abstract: In addition to the fracture energy and impact strength, two important indicators of ballistic performance

Keywords： projectile impact     depth of penetration     fracture energy     crater diameter     UHPFRC    

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Hazard potential of zones of weakness in gravity dams under impact loading conditions

Herbert LINSBAUER

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 1,   Pages 90-97 doi: 10.1007/s11709-010-0008-3

Abstract: to “dynamic loading” in the form of seismic action on the dam-reservoir-system and alternatively by “impact

Keywords： dam-reservoir     earthquake     impact     cracking     fracture mechanics    

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Buffer capacity of granular matter to impact of spherical projectile based on discrete element method

Ying YAN, Pengfei LI, Shunying JI

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 1,   Pages 50-54 doi: 10.1007/s11709-013-0186-x

Abstract: Granular matter possesses impact-absorbing property due to its energy dissipation character.To investigate the impact-absorbing capacity of granular matter, the discrete element method (DEM) isadopted to simulate the impact of a spherical projectile on to a granular bed.The penetration depth of the projectile and the first impact peak are investigated with different bedthicknesses and impact velocities.

Keywords： granular matter     impact peak     buffer capacity     discrete element method     critical thickness    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 877-894 doi: 10.1007/s11709-021-0756-2

Abstract: Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic load model. Measured multi-lane traffic data generally exhibit significant lane disparities in traffic loads over multiple lanes. However, these disparities are not considered in current specifications. To address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic statistical approach that considers the presence of multiple trucks. The proposed MLF model and approach were calibrated and demonstrated through an example site. The model sensitivity analysis demonstrated the significant influence of lane disparity of truck traffic volume and truck weight distribution on the MLF. Using the proposed approach, the experimental site study yielded MLFs comparable with those directly calculated using traffic load effects. The exclusion of overloaded trucks caused the proposed approach, existing design specifications, and conventional approach of ignoring lane load disparity to generate comparable MLFs, while the MLFs based on the proposed approach were the most comprehensive. The inclusion of overloaded trucks caused the conventional approach and design specifications to overestimate the MLFs significantly. Finally, the benefits of the research results to bridge practitioners were discussed.

Keywords： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion    

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Title Author Date Type Operation

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu

Journal Article

Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey of the English literature

Zhiping Yang, Qiong Wu, Kaichun Wu, Daiming Fan

Journal Article

Game theoretic analysis of environmental impact assessment system in China

CHENG Hongguang, PU Xiao, GONG Li, QI Ye

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Dynamical analysis of droplet impact spreading on solid substrate

Zhaomiao LIU, Huamin LIU, Xin LIU,

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Journal Article

Comparison of droplet distributions from fluidic and impact sprinklers

Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU

Journal Article

Mechanical properties and impact resistance of concrete composites with hybrid steel fibers

Fatih ÖZALP; Halit Dilşad YILMAZ; Burcu AKCAY

Journal Article

Hazard potential of zones of weakness in gravity dams under impact loading conditions

Herbert LINSBAUER

Journal Article

Buffer capacity of granular matter to impact of spherical projectile based on discrete element method

Ying YAN, Pengfei LI, Shunying JI

Journal Article

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Journal Article